- O'Brien, Conan
- O'Brien, Edmond
- O'Connor, Carroll
- O'Connor, Kevin J
- O'Connor, Sinead
- O'Donnell, Chris
- O'Donnell, Rosie
- O'Hara, David
- O'Hara, Maureen
- O'Neal, Tatum
- O'Sullivan, Maureen
- O'Toole, Peter
- Oakenfold, Paul
- Obama, Malia
- Obama, Michelle
- Obama, Sasha
- Oberon, Merle
- Ocasek, Ric
- Olbermann, Keith
- Oldman, Gary
- Olin, Lena
- Olivier, Laurence
- Olmos, Edward James
- Olsen, Ashley
- Olsen, Mary-Kate
- Onassis, Jacqueline Kennedy
- Ono, Yoko
- Orbach, Jerry
- Orbison, Roy
- Ormond, Julia
- Osborne, Jeffrey
- Osborne, Joan
- Osbourne, Ozzy
- Osmond, Donny
- OutKast
- Overmyer, Amanda
- Owens, Chris
